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Diflucan belongs to the group of triazole anti-fungal medications. It selectively stop sterol synthesis in the cells of fungal organisms. When applied to animals, experience has shown activity Diflucan different types of fungal infections. The drug was actually acts against opportunistic fungal infections caused by Candida, including Candida widespread in people with a weak immune system, against Cryptococcus disease causing intracerebral infections, Microsporum and Trychoptyton. It showed the activity of fluconazole (Diflucan of the asset) against types of endemic mycoses, including infections caused by Blastomyces Coccidioides immitis, including intracranial infections as well.
Fluconazole has high level of specificity of fungal enzymes, which are dependent on cytochrome P450. Diflucan therapy was prescribed a daily dose of 50 mg for 28 days did not affect the concentration of testosterone in the plasma of men or the concentration of steroids in young women. Fluconazole at doses of 200-400 mg provided no influence on the level of endogenous steroids.
The addition of 50 mg of fluconazole not influence the metabolism antipirin in the case of their combination therapy.
It has been shown the case of secondary infections caused by different strains of Candida albicans, which were not sufficiently sensitive to fluconazole (eg, Candida krusei). In these cases, alternative antifungal therapy may be prescribed.
Fluconazole is well absorbed, its level in the blood plasma and bioavailability is generally greater than 90%. Meals are not influence the absorption of Diflucan. The maximum concentration begins to 0.5-1.5 hours after taking fluconazole on an empty stomach. Concentration in blood plasma is proportional to the amount of the dose. 90% of the equilibrium concentration is reached in the 4th or 5th day of treatment.
Fluconazole is well into body fluids. Levels of fluconazole in saliva and mucus are similar to its concentration in the blood plasma. In patients with fungal meningitis in fluconazole in the spinal fluid is equal to 80% compared to the level in the blood plasma.
Diflucan is mainly out with the help of kidney almost 80% can be found in the urine.
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Cold sores are caused by herpes simplex virus 1 Unfortunately, modern medicine has no cure for the treatment of herpes virus and completely restore the patient. However, this disease is not as bad as it may seem to you. Learning requires a cold sore and its management that you will be able to live with the disease are not likely to people who are in constant contact with you.
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